Chembiotech: 6-[(Cyanoethyl)thio]-7-deaza-dG (pac) CE-phosphoramidite

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Modified Phosphoramidites , class 7-Deazapurine Nucleoside Phosphoramidites

Catalog #	CBT-P-025
Compound	6-[(Cyanoethyl)thio]-7-deaza-dG (pac) CE-phosphoramidite
Chemical Name	4-[(2-Cyanoethyl)thio]-7-[2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-ß-D-erythro-pentofuranosyl]-2-[(phenoxyacet)amino]-7H-pyrrolo[2,3-d]pyrimidine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
Formula	C₅₂H₅₈N₇O₈PS
Molecular Weight	972.10 g/mol
Properties	Storage at -18°C A new protocol for the covalent attachment of oligonucleotides to gold nanoparticles was developed using 6-thio-7-deaza-2’-deoxyguanosine as molecular surface anchor. Compared to already existing conjugation protocols, the new linker strategy simplifies the synthesis of DNA gold nanoparticle conjugates. Incorporation of the sulfur-containing nucleosides can be performed at any position of an oligonucleotide; even multiple incorporations are feasible, which increases the binding stability of the corresponding oligonucleotides to the gold nanoparticles.
Appearance	Off-white foam
References	F. Seela, P. Ding, S. Budow, Bioconjugate Chem. 2011, 22, 794.

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