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7-Bromo-2-amino-8-aza-7-deaza-dA (formyl, di-n-butyl) CE-phosphoramidite
Modified Phosphoramidites , class Halogenated Phosphoramidites
7-Bromo-2-amino-8-aza-7-deaza-dA (formyl, di-n-butyl) CE-phosphoramidite
Catalog # CBT-P-102
Compound 7-Bromo-2-amino-8-aza-7-deaza-dA (formyl, di-n-butyl) CE-phosphoramidite
Chemical Name 3-Bromo-1-[2-deoxy-5-O-(4,4-dimethoxytrityl)-ß-D-erythro-pentofuranosyl]-4-[[(di-n-butylamino)methylidene]amino]-6-[(formyl)amino)]-1H-pyrazolo[3,4-d]pyrimidin-4,6-diamine 3-[(2-cyanoethyl)-N,N-(diisopropyl)]-phosphoramidite
Formula C50H65BrN9O7P
Molecular Weight 1014.99 g/mol
Properties Storage at -18°C

Our phosphoramidite building block CBT-P-102 can be employed in solid-phase oligonucleotide synthesis under standard conditions. Also, standard protocols can be used for the deprotection of the resulting oligonucleotides. 7-Bromo-2-amino-8-aza-7-deaza-dA has a significantly stabilized N-glycosylic bond compared to the corresponding, rather labile 2,6-diaminopurine 2'-deoxyribonucleoside analog and forms a tridentate base pair with dT, which is as strong as the canonical dG-dC pair. In addition, as a constituent of oligonucleotides, this nucleoside shows similiar base pair discriminatory properties as dA.
Appearance Colorless foam
References F. Seela, G. Becher, Nucleic Acids Res. 2001, 29, 2069.
G. Becher, F. Seela, J. He, Helv. Chim. Acta 2001, 84, 1048.
QuantityPricing (EUR)
50 µmol 250,00
100 µmol 450,00
250 mg 1 000,00
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