ChemBiotech
Phone +49 (0)251-53406-505/858
Mobile phone +49 (0)173-7250-297
Fax +49 (0)251-53406-857
E-Mail dna@chembiotech.de

© ChemBiotech 2024
7-Deaza-dG (ibu) CE-phosphoramidite
Modified Phosphoramidites , class 7-Deazapurine Nucleoside Phosphoramidites
7-Deaza-dG (ibu) CE-phosphoramidite
Catalog # CBT-P-021
Compound 7-Deaza-dG (ibu) CE-phosphoramidite
Chemical Name 7-[2-Deoxy-5-O-(4,4'-dimethoxytrityl)-ß-D-erythro-pentofuranosyl]-3,7-dihydro-2-[(isobutyryl)amino]-4H-pyrrolo[2,3-d]pyrimidin-4-one 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
Formula C45H55N6O8P
Molecular Weight 838.93 g/mol
Properties Storage at -18°C

Phosphoramidites of 7-deaza-2’-deoxyguanosine (7-deaza-dG) were first prepared in 1985 by Seela and co-workers. Oligonucleotides containing 7-deaza-dG give higher sensitivity in MALDI-TOF spectrometry due to the rather stable glycosidic bond under acidic conditions. The incorporation of this modified nucleoside in place of dG destroys dG-quartets, thereby prohibiting oligonucleotide aggregation during gel electrophoresis or PCR-amplification. Multiple incorporations of 7-deaza-dG might require milder oxidation reagents or the use of our product CBT-P-160.
Appearance Off-white foam
References F. Seela, H. Driller, Nucleic Acids Res. 1985, 13, 911.
F. Seela, H. Driller, Nucleic Acids Res. 1989, 17, 901.
QuantityPricing (EUR)
50 µmol 180,00 €
100 µmol 320,00 €
250 mg 850,00 €
Order now
For bulk quantities request by e-Mail: dna@chembiotech.de or phone: +49 251 53406 858 or +49 251 53406 505.