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7-Deaza-dA (ibu) CE-phosphoramidite
Modified Phosphoramidites , class 7-Deazapurine Nucleoside Phosphoramidites
7-Deaza-dA (ibu) CE-phosphoramidite
Catalog # CBT-P-011
Compound 7-Deaza-dA (ibu) CE-phosphoramidite
Chemical Name 7-[2-Deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-ß-D-erythro-pentofuranosyl]-4-[(isobutyryl)amino]-7H-pyrrolo[2,3-d]pyrimidine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
Formula C45H55N6O7P
Molecular Weight 822.94 g/mol
Properties Storage at -18°C

Phosphoramidites of 7-deaza-2’-deoxyadenosine (7-deaza-dA) were first described by Seela and coworkers. As the nucleoside is remarkably stable under acidic conditions, oligonucleotides do not “depurinate”. Thus, they are used in MALDI-TOF spectrometry to enhance peak sensitivity. The nucleoside also prevents cleavage of oligonucleotides by nucleases. In addition, the absence of nitrogen-7 provides useful information in the detection of DNA-enzyme binding sites.
Appearance Off-white foam
References F. Seela, A. Kehne, Biochemistry 1985, 24, 7556.
F. Seela, A. Kehne, Biochemistry 1987, 26, 2232.
QuantityPricing (EUR)
50 µmol 180,00 €
100 µmol 320,00 €
250 mg 850,00 €
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